منابع مشابه
Prospects in Adoptive Cell Transfer Therapy for Cancer
It has been documented that immunosurveillance plays an important role in cancer development in both human and animals [1,2]. Cancer immunosurveillance is the function of immune system in recognizing and reacting against aberrant cancer cells in the body. Thus, the interactions between cancer cells and immune cells play a pivotal role in cancer development. In cancer patients, however, tumors g...
متن کاملastases with Adoptive Cell Therapy
ownloade pose: To determine the objective response rate and response duration of melanoma brain metaso adoptive cell therapy (ACT) with autologous antitumor lymphocytes plus interleukin-2 following phodepleting preparative regimen. hods: Between 2000 and 2009, 264 patients with metastatic melanoma received ACT, consisting of hosphamide and fludarabine with or without total body irradiation, fol...
متن کاملAdoptive T-cell transfer therapy and oncogene-targeted therapy for melanoma: the search for synergy.
The clinical strengths of immunotherapy and small-molecule inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway appear to be largely complementary for the treatment of advanced melanoma. In current practice, most patients with BRAF V600 mutant melanomas will see both modalities. Several in vitro and in vivo studies suggest that combining immunotherapy with MAPK inhibition ma...
متن کاملPrinciples of adoptive T cell cancer therapy.
The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for viral infections and has induced regression of cancer in early-stage clinical trials. However, recent advances in cellular immunology and tumor biology are guiding new approaches to adoptive T cell therapy. For example, use of engineered T cells is being tested as a strategy to improve the functions o...
متن کاملT-cell-based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition.
Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their...
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ژورنال
عنوان ژورنال: Seminars in Oncology
سال: 2007
ISSN: 0093-7754
DOI: 10.1053/j.seminoncol.2007.09.002